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Article

Hypoxia-inducible factor 2alpha binds to cobalt in vitro.

Biochemical and biophysical research communications - 9 Nov 2001

Yuan Y, Beitner-Johnson D, Millhorn D E

Abstract excerpt

The hypoxia-inducible factor (HIF) activates the expression of genes that contain a hypoxia response element (HRE). The alpha subunit of the HIF transcription factors is degraded by proteasome pathways during normoxia, but stabilized under hypoxic conditions. It has previously been established that cobalt causes accumulation of HIF-2alpha and HIF-1alpha. However, little is known about the mechanism by which...

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PMID: 11688986
DOI: 10.1006/bbrc.2001.5835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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