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Article

Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner.

Mitochondrion - 1 Jul 2021

Uba Takeo, Matsuo Yoshiyuki, Sumi Chisato, Shoji Tomohiro, Nishi Kenichiro, Kusunoki Munenori, Harada Hiroshi, Kimura Hideo, Bono Hidemasa, Hirota Kiichi

Abstract excerpt

In cellular signaling, the diverse physiological actions of biological gases, including O2, CO, NO, and H2S, have attracted much interest. Hypoxia-inducible factors (HIFs), including HIF-1 and HIF-2, are transcription factors that respond to reduced intracellular O2 availability. Polysulfides are substances containing varying numbers of sulfur atoms (H2Sn) that are generated endogenously from H2S by...

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Identifiers

PMID: 34133955
DOI: 10.1016/j.mito.2021.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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