Article
Genes and gastric cancer.
Hepato-gastroenterology - 1 Jan 2000
Kyrlagkitsis Ioannis, Karamanolis D G
Abstract excerpt
Gastric cancer remains quite a common malignancy and counts among the most important causes of cancer-related death worldwide. Although the pathogenesis is multifactorial, familial aggregation in a significant proportion of cases suggests the importance of genetic predisposition. The association between the E-cadherin/CDH1 gene germline mutations and the development of diffuse gastric cancer was the first...
Topics
- Cadherins
- Carbohydrate Dehydrogenases
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Gastrectomy
- Genetic Predisposition to Disease
- Genetic Therapy
- Germ-Line Mutation
- Humans
- Loss of Heterozygosity
- Microsatellite Repeats
- Prognosis