Familial gastric cancer: genetic susceptibility, pathology, and implications for management.

doi:10.1016/S1470-2045(14)71016-2

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Article

Familial gastric cancer: genetic susceptibility, pathology, and implications for management.

The Lancet. Oncology - 1 Feb 2015

Oliveira Carla, Pinheiro Hugo, Figueiredo Joana, Seruca Raquel, Carneiro Fátima

Abstract excerpt

Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastric cancer. The risk of development of gastric cancer is high in families affected b-y these syndromes, but only hereditary diffuse gastric cancer is genetically explained (caused by germline alterations of CDH1, which...

Topics

Genetic Predisposition to Disease
Humans
Stomach Neoplasms

Source

Open in PubMed

Identifiers

PMID: 25638682
DOI: 10.1016/S1470-2045(14)71016-2

Genes

CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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