Article
Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.
Cancer research - 1 Apr 1998
McDonald J M, Douglass E C, Fisher R, Geiser C F, Krill C E, Strong L C, Virshup D, Huff V
Abstract excerpt
Familial predisposition to Wilms' tumor (WT), a childhood kidney tumor, is inherited as an autosomal dominant trait. For most WT families studied, the 11p13 gene WT1 and genomic regions implicated in tumorigenesis in a subset of tumors can be ruled out as the site of the familial predisposition g...
Topics
- Child, Preschool
- Chromosomes, Human, Pair 19
- Disease Susceptibility
- Family Health
- Female
- Genetic Linkage
- Humans
- Loss of Heterozygosity
- Male
- Models, Genetic
- Mutation
- Pedigree