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Article

Genetic and Epigenetic Drivers of Wilms Tumor Predisposition in Russian Pediatric Patients: A Multicenter Study.

International journal of molecular sciences - 1 May 2026

Semenova Vera, Sagoyan Garik, Zhukovskaya Elena, Kozlova Valentina, Gegelia Nina, Mitrofanova Anna, Suleymanova Amina, Druy Alexander, Zelenova Ekaterina, Pavlov Vladislav, Rubanskay Marina, Karelin Alexander, Varfolomeeva Svetlana, Nasedkina Tatiana

Abstract excerpt

Wilms tumor (WT), the most common kidney neoplasm in children, is closely associated with hereditary factors. This study included 134 WT patients (62 males, median age of 7 years, age at diagnosis of 24.9 months) with unilateral (n = 90, 67%) or bilateral WT (n = 44, 33%). Genetic testing was performed using targeted sequencing of 415 genes and multiplex ligation-dependent probe amplification (MLPA). Twenty-five...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42123644
DOI: 10.3390/ijms27094066
PMCID: PMC13164404

Genes

BRCA2
CDC73
CHEK2
NF1
RAD50
REST
TRIM28
WT1

Provenance

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