Familial Wilms tumor.

doi:10.1002/ajmg.c.30025

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Article

Familial Wilms tumor.

American journal of medical genetics. Part C, Seminars in medical genetics - 15 Aug 2004

Ruteshouser E Cristy, Huff Vicki

Abstract excerpt

Wilms tumor (WT), an embryonic tumor arising from undifferentiated renal mesenchyme, has been a productive model for understanding the role of genes in both tumorigenesis and normal organogenesis. Approximately 2% of WT patients have a family history of WT, and even sporadic WT is thought to have a strong genetic component to its etiology. Familial WT cases generally have an earlier age of onset and an increased...

Topics

Child, Preschool
Genes, Wilms Tumor
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Kidney Neoplasms
Pedigree
Wilms Tumor

Source

Open in PubMed

Identifiers

PMID: 15264270
DOI: 10.1002/ajmg.c.30025

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