Article
Prevalence of (Epi)genetic Predisposing Factors in a 5-Year Unselected National Wilms Tumor Cohort: A Comprehensive Clinical and Genomic Characterization.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jun 2022
Hol Janna A, Kuiper Roland P, van Dijk Freerk, Waanders Esmé, van Peer Sophie E, Koudijs Marco J, Bladergroen Reno, van Reijmersdal Simon V, Morgado Lionel M, Bliek Jet, Lombardi Maria Paola, Hopman Saskia, Drost Jarno, de Krijger Ronald R, van den Heuvel-Eibrink Marry M, Jongmans Marjolijn C J
Abstract excerpt
PURPOSE: Wilms tumor (WT) is associated with (epi)genetic predisposing factors affecting a growing number of WT predisposing genes and loci, including those causing Beckwith-Wiedemann spectrum (BWSp) or WT1-related syndromes. To guide genetic counseling and testing, we need insight into the prevalence of WT predisposing (epi)genetic factors. PATIENTS AND METHODS: All children diagnosed with WT in the Netherlands...
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