Article
A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults.
Annals of hepatology - 1 Jan 2025
Maponga Tongai G, McNaughton Anna L, Campbell Cori, de Cesare Mariateresa, Mokaya Jolynne, Lumley Sheila F, Bonsall David, Ip Camilla Lc, Chai Haiting, Van Rensburg Christo, Glashoff Richard H, Waddilove Elizabeth, Preiser Wolfgang, Blackard Jason T, Ansari M Azim, Kramvis Anna, Andersson Monique I, Matthews Philippa C
Abstract excerpt
INTRODUCTION AND OBJECTIVES: Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). In African populations, HCC frequently presents at an advanced stage with poor outcomes. We applied whole genome sequencing (WGS) to compare HBV genomes in individuals with and without HCC. MATERIALS AND METHODS: We identified adults with HBV infection, with and without complicating...
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