Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.

doi:10.1186/1471-2407-11-458

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Article

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.

BMC cancer - 21 Oct 2011

Tatsukawa Masashi, Takaki Akinobu, Shiraha Hidenori, Koike Kazuko, Iwasaki Yoshiaki, Kobashi Haruhiko, Fujioka Shin-Ichi, Sakaguchi Kohsaku, Yamamoto Kazuhide

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV) is a major cause of hepatocarcinogenesis.To identify mutations relevant to hepatocellular carcinoma (HCC) development, we compared the full genome sequences of HBV from the sera of patients with and without HCC. METHODS: We compared the full genome sequences of HBV isolates from 37 HCC patients (HCC group 1) and 38 patients without HCC (non-HCC group 1). We also investigated...

Topics

Adult
Aged
Carcinoma, Hepatocellular
DNA Mutational Analysis
DNA, Viral
Female
Genes, Viral
Genotype
Hepatitis B virus
Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver Neoplasms

Male

Middle Aged

Multivariate Analysis

Mutation

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22014121
DOI: 10.1186/1471-2407-11-458
PMCID: PMC3214198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22014121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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