Article
Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.
BMC cancer - 21 Oct 2011
Tatsukawa Masashi, Takaki Akinobu, Shiraha Hidenori, Koike Kazuko, Iwasaki Yoshiaki, Kobashi Haruhiko, Fujioka Shin-Ichi, Sakaguchi Kohsaku, Yamamoto Kazuhide
Abstract excerpt
BACKGROUND: Hepatitis B virus (HBV) is a major cause of hepatocarcinogenesis.To identify mutations relevant to hepatocellular carcinoma (HCC) development, we compared the full genome sequences of HBV from the sera of patients with and without HCC. METHODS: We compared the full genome sequences of HBV isolates from 37 HCC patients (HCC group 1) and 38 patients without HCC (non-HCC group 1). We also investigated...
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