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Article

Combined mutations in pre-s/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study.

The Journal of infectious diseases - 1 Dec 2008

Chen Chien-Hung, Changchien Chi-Sin, Lee Chuan-Mo, Hung Chao-Hung, Hu Tsung-Hui, Wang Jing-Houng, Wang Jyh-Chwan, Lu Sheng-Nan

Abstract excerpt

BACKGROUND: We sought to investigate the role of sequence variations in pre-S/surface and basal core promoter (BCP)/precore regions of the hepatitis B virus (HBV) in hepatocellular carcinoma (HCC). METHODS: The direct sequencing in pre-S/surface and BCP/precore regions of HBV was determined for 80 patients with HCC and 160 control patients with HBV infection. RESULTS: Compared with control patients, patients with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18939932
DOI: 10.1086/592990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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