Article
Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound.
Acta dermato-venereologica - 1 Mar 1998
Helsby N A, Ward S A, Parslew R A, Friedmann P S, Rhodes L E
Abstract excerpt
Retinol and proguanil are metabolised by the same family of hepatic cytochrome P450, i.e. CYP2C. We used proguanil as a probe to study CYP2C activity, and by implication retinol metabolism, in psoriasis. In vitro studies showed that retinol competitively inhibited the hepatic metabolism of proguanil to cycloguanil. Proguanil metabolism was assessed in 82 patients with chronic plaque psoriasis. Following proguanil...
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