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Article

Blockade of growth hormone receptor shedding by a metalloprotease inhibitor.

Endocrinology - 1 Apr 1998

Alele J, Jiang J, Goldsmith J F, Yang X, Maheshwari H G, Black R A, Baumann G, Frank S J

Abstract excerpt

GH, an important growth-promoting and metabolic hormone, exerts its biological effects by interacting with cell surface GH receptors (GHRs). The GHR is a single membrane-spanning protein that binds GH via its extracellular domain. The high affinity GH-binding protein (GHBP), which corresponds to a soluble form of the GHR extracellular domain, carries a substantial fraction of the GH in the circulation of various...

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Identifiers

PMID: 9528979
DOI: 10.1210/endo.139.4.5906

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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