Article
Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2007
van den Eijnden Monique J, Strous Ger J
Abstract excerpt
GH and GH receptor are expressed in many extrapituitary tissues, permitting autocrine/paracrine activity. Autocrine GH has regulatory functions in embryonic development and cellular differentiation and proliferation and is reported to be involved in the development and metastasis of tumor cells. To understand the principles of transport and signaling of autocrine GH and GH receptor, we used a model system to...
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