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Article

Growth hormone excess and the development of growth hormone receptor antagonists.

Experimental physiology - 1 Nov 2008

Higham C E, Trainer P J

Abstract excerpt

In 1990, a single amino acid substitution in the growth hormone (GH) gene at position 119 was found to transform the consequent protein from an agonist to an antagonist at the growth hormone receptor (GHR). Further amino acid substitutions plus prolongation of the half-life of the protein by pegylation resulted in the first clinically effective GHR antagonist, pegvisomant. Following extensive clinical trials,...

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Source

Identifiers

PMID: 18617577
DOI: 10.1113/expphysiol.2008.042515

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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