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Article

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1 Apr 1998

Abstract excerpt

Proliferation of human mammary epithelial cells (HMEC) is limited to a few passages in culture due to an arrest in G1 termed selection or mortality stage 0, M0. A small number of cells spontaneously escape M0, continue to proliferate in culture, and then enter a second mortality stage, M1, at which they senesce. Evidence that M0 involves the Rb pathway comes from the observation that expression of human...

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Identifiers

PMID: 9528751
DOI: 10.1128/mcb.18.4.1793

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