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Article

<i>In situ</i> detection of the hypermethylation-induced inactivation of the <i>p16</i> gene as an early event in oncogenesis

26 Oct 1999

Abstract excerpt

We have developed a technique, methylation-specific PCR in situ hybridization (MSP-ISH), which allows for the methylation status of specific DNA sequences to be visualized in individual cells. We use MSP-ISH to monitor the timing and consequences of aberrant hypermethylation of the p16 tumor suppresser gene during the progression of cancers of the lung and cervix. Hypermethylation of p16 was localized only to the...

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PMID: 10535995
DOI: 10.1073/pnas.96.22.12754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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