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Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein

1 Feb 2010

Abstract excerpt

A common feature shared between several human cancer-associated viruses, such as Epstein-Barr virus, Hepatitis B virus and Hepatitis C virus, and Human papillomavirus (HPV) is the ability to reduce the expression of cellular E-cadherin. Since E-cadherin is used by Langerhans cells to move through the stratified epithelium, its reduction may affect the efficiency by which the immune system responds to HPV...

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PMID: 20123756
DOI: 10.1093/carcin/bgq027

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