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Article

Investigating the role of Sterol C24-Methyl transferase mutation on drug resistance in leishmaniasis and identifying potential inhibitors.

Journal of biomolecular structure & dynamics - 1 Jan 2024

Khan Huma, Waqas Muhammad, Khurshid Beenish, Ullah Nazif, Khalid Asaad, Abdalla Ashraf N, Alamri Mubarak A, Wadood Abdul

Abstract excerpt

Leishmaniasis is a fatal disease caused by the leishmania parasite. For the survival of the leishmania parasite, Sterol C24-Methyl Transferase (SMT) is essential which is an enzyme of the ergosterol pathway. SMT protein mutation is responsible for Amphotericin-B drug resistance in Leishmania, which is the main treatment for visceral leishmaniasis. Amphotericin-B resistance is caused by three mutated residues...

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Identifiers

PMID: 37723868
DOI: 10.1080/07391102.2023.2256879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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