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Article

Increased DNA unwinding efficiency of bacteriophage T7 DNA helicase mutant protein 4A'/E348K.

The Journal of biological chemistry - 3 Apr 1998

Washington M T, Patel S S

Abstract excerpt

Bacteriophage T7 4A' protein is a DNA helicase that unwinds DNA in a reaction coupled to dTTP hydrolysis. To understand better its mechanism of DNA unwinding, we characterized a set of 4A' mutant proteins (Washington, M. T., Rosenberg, A. H., Griffin, K., Studier, F. W., and Patel, S. S. (1996) J. Biol. Chem. 271, 26825-26834). We showed here, using single turnover DNA unwinding assays, that the 4A'/E348K mutant...

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PMID: 9525882
DOI: 10.1074/jbc.273.14.7880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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