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Article

Mutations altering the interplay between GkDnaC helicase and DNA reveal an insight into helicase unwinding.

PloS one - 1 Jan 2011

Lo Yu-Hua, Liu Shih-Wei, Sun Yuh-Ju, Li Hung-Wen, Lizz Hung-Wen, Hsiao Chwan-Deng

Abstract excerpt

Replicative helicases are essential molecular machines that utilize energy derived from NTP hydrolysis to move along nucleic acids and to unwind double-stranded DNA (dsDNA). Our earlier crystal structure of the hexameric helicase from Geobacillus kaustophilus HTA426 (GkDnaC) in complex with single-stranded DNA (ssDNA) suggested several key residues responsible for DNA binding that likely play a role in DNA...

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PMID: 22174946
DOI: 10.1371/journal.pone.0029016
PMCID: PMC3236778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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