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Article

The oncogenic potential of hepatitis C virus NS5A sequence variants is associated with PKR regulation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2005

Giménez-Barcons Mireia, Wang Chunfu, Chen Ming, Sánchez-Tapias José-María, Sáiz Juan-Carlos, Gale Michael

Abstract excerpt

The NS5A protein of hepatitis C virus (HCV) confers cell growth regulation and has been implicated in viral oncogenesis. Here, we investigated whether highly divergent NS5A proteins obtained from HCV-infected patients presented an oncogenic potential when expressed in mammalian cells. In general, NS5A expression was associated with increased rates of cell growth and culture proliferation. Immortalized primary...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15767789
DOI: 10.1089/jir.2005.25.152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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