Article
In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients.
European journal of nuclear medicine - 1 Feb 1997
Vecchio S D, Ciarmiello A, Potena M I, Carriero M V, Mainolfi C, Botti G, Thomas R, Cerra M, D'Aiuto G, Tsuruo T, Salvatore M
Abstract excerpt
Technetium-99m sestamibi is a transport substrate recognised by the multidrug-resistant P-glycoprotein (Pgp). To test whether 99mTc-sestamibi efflux is enhanced in breast carcinomas overexpressing Pgp, we determined the efflux rates of 99mTc-sestamibi and Pgp levels in tumours from 30 patients wi...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Autoradiography
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Female
- Humans
- Immunoenzyme Techniques
- Middle Aged
- Phenotype
- Radionuclide Imaging