Article
A possible allosteric communication pathway identified through a resonance Raman study of four beta37 mutants of human hemoglobin A.
Biochemistry - 31 Mar 1998
Peterson E S, Friedman J M
Abstract excerpt
The highly conserved tryptophan at position beta37 occupies a key locus at the hinge region within the alpha1beta2 interface of the mammalian hemoglobins. This residue is thought to play an important role in mediating the heme-heme interaction associated with the cooperative binding of oxygen; however, its explicit function is unclear. In this study, the proximal heme environments of several beta37 mutants of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.