Article
A resonance Raman enhancement mechanism for axial vibrational modes in the pyridine adduct of myoglobin proximal cavity mutant (H93G).
The journal of physical chemistry. B - 6 Sept 2012
Franzen Stefan, Brown Derek, Gaff John, Delley B
Abstract excerpt
The proximal cavity mutant of myoglobin consists of a mutation of the proximal histidine to glycine (H93G), which permits exogenous ligands to bind to the heme iron. A non-native pyridine ligand can ligate to the heme to yield a five-coordinate adduct, H93G(Pyr), that cannot be formed freely in solution since the six-coordinate bis-pyridine adduct is more stable than the five-coordinate adduct. We have used...
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