Article
Near-UV circular dichroism and UV resonance Raman spectra of individual tryptophan residues in human hemoglobin and their changes upon the quaternary structure transition.
Biochemistry - 31 Jul 2012
Nagai Masako, Nagatomo Shigenori, Nagai Yukifumi, Ohkubo Kenichi, Imai Kiyohiro, Kitagawa Teizo
Abstract excerpt
The aromatic residues such as tryptophan (Trp) and tyrosine (Tyr) in human adult hemoglobin (Hb A) are known to contribute to near-UV circular dichroism (CD) and UV resonance Raman (RR) spectral changes upon the R → T quaternary structure transition. In Hb A, there are three Trp residues per αβ dimer: at α14, β15, and β37. To evaluate their individual contributions to the R → T spectral changes, we produced three...
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