High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,.

doi:10.1021/bi9708702

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Article

High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,.

Biochemistry - 31 Mar 1998

Kavanaugh J S, Weydert J A, Rogers P H, Arnone A

Abstract excerpt

The high-resolution X-ray structures of the deoxy forms of four recombinant hemoglobins in which Trp37(C3)beta is replaced with Tyr (betaW37Y), Ala (betaW37A), Glu (betaW37E), or Gly (betaW37G) have been refined and analyzed with superposition methods that partition mutation-induced perturbations...

Topics

Amino Acid Substitution
Crystallization
Crystallography, X-Ray
Hemoglobin A
Humans
Models, Molecular
Mutation
Protein Conformation
Protein Structure, Tertiary
Reproducibility of Results
Tryptophan

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