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Article

Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes

16 Mar 1999

Abstract excerpt

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa...

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PMID: 10077617
DOI: 10.1073/pnas.96.6.2949

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