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Article

Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors.

The EMBO journal - 15 Aug 2003

Viloria-Petit Alicia, Miquerol Lucile, Yu Joanne L, Gertsenstein Marina, Sheehan Capucine, May Linda, Henkin Jack, Lobe Corrinne, Nagy Andras, Kerbel Robert S, Rak Janusz

Abstract excerpt

Previous gene targeting studies have implicated an indispensable role of vascular endothelial growth factor (VEGF) in tumor angiogenesis, particularly in tumors of embryonal or endocrine origin. In contrast, we report here that transformation of VEGF-deficient adult fibroblasts (MDF528) with ras...

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Identifiers

PMID: 12912908
DOI: 10.1093/emboj/cdg408
PMCID: PMC176189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12912908-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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