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Article

Chronic exposure of VEGF inhibitors promotes the malignant phenotype of colorectal cancer cells.

The journal of medical investigation : JMI - 1 Jan 2015

Tomida Chisato, Yamagishi Naoko, Aibara Kana, Yano Chiaki, Uchida Takayuki, Abe Tomoki, Ohno Ayako, Hirasaka Katsuya, Nikawa Takeshi, Teshima-Kondo Shigetada

Abstract excerpt

VEGF-targeting anti-angiogenic drugs have enabled significant advances in cancer therapy. However, acquired resistance to VEGF-targeting drugs occurs, leading to disease progression. How tumors become the resistance remains fully uncertain. One of possible mechanisms for the resistance may be the direct effect of VEGF inhibitors on tumor cells expressing VEGF receptors (VEGF-R). We investigated here the direct...

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Identifiers

PMID: 25817288
DOI: 10.2152/jmi.62.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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