Article
Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
Journal of molecular biology - 5 Apr 1996
Longenecker K L, Roach P J, Hurley T D
Abstract excerpt
The three-dimensional structure for the catalytic region of the mammalian protein kinase, casein kinase I delta (CKI delta), has been solved by X-ray crystallography to a resolution of 2.3 A. A truncation mutant of CKI delta lacking the C-terminal autoinhibitory region was expressed in Escherichia coli, purified, and crystallized. The structure was solved by molecular replacement using the crystal structure of...
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