Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.

Biophysical journal - 19 Dec 2017

Dahal Liza, Kwan Tristan O C, Shammas Sarah L, Clarke Jane

Abstract excerpt

Understanding the detailed mechanism of interaction of intrinsically disordered proteins with their partners is crucial to comprehend their functions in signaling and transcription. Through its interaction with KIX, the disordered pKID region of CREB protein is central in the transcription of cAMP responsive genes, including those involved in long-term memory. Numerous simulation studies have investigated these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP Response Element-Binding Protein
Share to Intrinsically Disordered Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutation

Share to Protein Binding

Share to Protein Domains

Share to Protein Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 29262364
DOI: 10.1016/j.bpj.2017.10.016
PMCID: PMC5770965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.PMID 29262364Read ↗

Atomistic details of the disordered states of KID and pKID. Implications in coupled binding and folding.Semantic proximity Read ↗

Mechanism of pKID/KIX Association Studied by Molecular Dynamics Free Energy Simulations.Semantic proximity Read ↗

Phosphorylation-induced transient intrinsic structure in the kinase-inducible domain of CREB facilitates its recognition by the KIX domain of CBP.Semantic proximity Read ↗

Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases.Semantic proximity Read ↗

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain.Semantic proximity Read ↗

The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state.Semantic proximity Read ↗

Tertiary structure prediction of the KIX domain of CBP using Monte Carlo simulations driven by restraints derived from multiple sequence alignments.Semantic proximity Read ↗

Phosphorylation Regulation on the Homo-Dimeric Binding of Transactive Response DNA-Binding Protein.Semantic proximity Read ↗

Folding perspectives of an intrinsically disordered transactivation domain and its single mutation breaking the folding propensity.Semantic proximity Read ↗

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.Semantic proximity Read ↗

KIF-Key Interactions Finder: A program to identify the key molecular interactions that regulate protein conformational changes.Semantic proximity Read ↗

Switching of the folding-energy landscape governs the allosteric activation of protein kinase A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.