Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

The Journal of biological chemistry - 27 Mar 1998

Radjendirane V, Joseph P, Lee Y H, Kimura S, Klein-Szanto A J, Gonzalez F J, Jaiswal A K

Abstract excerpt

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress. To examine the in vivo role of NQO1, a NQO1-null mouse was produced using targeted gene disruption. Mice lacking NQO1 gene expression showed no detectable phenotype and were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to DNA
Share to Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Phenotype

Share to Recombination, Genetic

Source

Identifiers

PMID: 9516435
DOI: 10.1074/jbc.273.13.7382

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.PMID 9516435Read ↗

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.Semantic proximity Read ↗

Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1.Semantic proximity Read ↗

Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family.Semantic proximity Read ↗

Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity.Semantic proximity Read ↗

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.Semantic proximity Read ↗

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.Semantic proximity Read ↗

Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease.Semantic proximity Read ↗

The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress.Semantic proximity Read ↗

A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.Semantic proximity Read ↗

Nrf2-Keap1 Signaling Pathway Regulates Human UGT1A1 Expression in Vitro and in Transgenic UGT1 MiceSemantic proximity Read ↗

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression.Semantic proximity Read ↗

Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.