Article
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.
Journal of molecular biology - 27 Nov 1998
Hsiou Y, Das K, Ding J, Clark A D, Kleim J P, Rösner M, Winkler I, Riess G, Hughes S H, Arnold E
Abstract excerpt
The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 (S-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroqui noxalin-2(1H)-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 infection in cell culture. HBY 097 selects for unus...
Topics
- Antiviral Agents
- Crystallography, X-Ray
- Drug Design
- Drug Resistance
- Glutamic Acid
- Glycine
- HIV Reverse Transcriptase
- Leucine
- Models, Molecular
- Molecular Conformation
- Mutation
- Quinoxalines
- Reverse Transcriptase Inhibitors