Article
Multiple threshold model for the onset of Alzheimer's disease in the NAS-NRC twin panel.
American journal of medical genetics - 7 Feb 1998
Meyer J M, Breitner J C
Abstract excerpt
The three common alleles at the APOE locus influence the onset and lifetime risk of typical late-onset Alzheimer's disease (AD). Other loci may also alter risk of late-onset AD. One may assess the relative influence of APOE on the genetic contribution to AD by estimating the proportion of AD heritability that is explained by APOE polymorphism. To do this requires an initial estimate of the heritability of AD....
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