Estimation of the proportion of genetic cases in late-onset diseases: an application to Alzheimer's disease.

doi:10.1002/sim.4780141208

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Article

Estimation of the proportion of genetic cases in late-onset diseases: an application to Alzheimer's disease.

Statistics in medicine - 30 Jun 1995

Tzourio C, Maccario J, Alpérovitch A

Abstract excerpt

In diseases with a complex etiology including a genetic component, an important issue is to determine the proportion of cases really having inherited the disease. This is not easy in late-onset diseases where censoring might obscure the transmission pattern of the disease and give an apparently n...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Female
Genetic Carrier Screening
Genotype
Humans
Likelihood Functions
Male
Middle Aged
Models, Genetic
Models, Statistical
Phenotype
Probability

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