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Article

Onset of Preclinical Alzheimer Disease in Monozygotic Twins.

Annals of neurology - 1 May 2021

Konijnenberg Elles, Tomassen Jori, den Braber Anouk, Ten Kate Mara, Yaqub Maqsood, Mulder Sandra D, Nivard Michel G, Vanderstichele Hugo, Lammertsma Adriaan A, Teunissen Charlotte E, van Berckel Bart N M, Boomsma Dorret I, Scheltens Philip, Tijms Betty M, Visser Pieter Jelle

Abstract excerpt

OBJECTIVE: The present work was undertaken to study the genetic contribution to the start of Alzheimer's disease (AD) with amyloid and tau biomarkers in cognitively intact older identical twins. METHODS: We studied in 96 monozygotic twin-pairs relationships between amyloid-beta (Aβ) aggregation as measured by the Aβ1-42/1-40 ratio in cerebrospinal fluid (CSF; n = 126) and positron emission tomography (PET, n =...

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Identifiers

PMID: 33583080
DOI: 10.1002/ana.26048
PMCID: PMC8251701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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