Article
The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA.
Nucleic acids research - 1 Apr 1998
Helm M, Brulé H, Degoul F, Cepanec C, Leroux J P, Giegé R, Florentz C
Abstract excerpt
Direct sequencing of human mitochondrial tRNALysshows the absence of editing and the occurrence of six modified nucleotides (m1A9, m2G10, Psi27, Psi28 and hypermodified nucleotides at positions U34 and A37). This tRNA folds into the expected cloverleaf, as confirmed by structural probing with nucleases. The solution structure of the corresponding in vitro transcript unexpectedly does not fold into a cloverleaf...
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