Article
Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility.
Nature structural biology - 1 Oct 2000
Kelley S O, Steinberg S V, Schimmel P
Abstract excerpt
Aminoacylation of transfer RNAs (tRNAs) is essential for protein synthesis. A growing number of human diseases correlate with point mutations in tRNA genes within the mitochondrial genome. These tRNAs have unique sequences that suggest they have fragile structures. However, the structural significance of pathology-related tRNA mutations and their effects on molecular function have not been explored. Here,...
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