Article
Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants.
RNA (New York, N.Y.) - 1 May 2004
Sissler Marie, Helm Mark, Frugier Magali, Giege Richard, Florentz Catherine
Abstract excerpt
In vitro transcription has proven to be a successful tool for preparation of functional RNAs, especially in the tRNA field, in which, despite the absence of post-transcriptional modifications, transcripts are correctly folded and functionally active. Human mitochondrial (mt) tRNA(Lys) deviates from this principle and folds into various inactive conformations, due to the absence of the post-transcriptional...
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