Article
Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts.
FEBS letters - 8 May 1998
Kato D, Miyazawa K, Ruas M, Starborg M, Wada I, Oka T, Sakai T, Peters G, Hara E
Abstract excerpt
The p16INK4A cyclin-dependent kinase (Cdk) inhibitor is now recognized as a major tumor suppressor that is inactivated by a variety of mechanisms in a wide range of human cancers. It is also implicated in the mechanisms underlying replicative senescence since p16INK4A RNA and protein accumulate a...
Topics
- Antennapedia Homeodomain Protein
- Cell Division
- Cell Nucleus
- Cells, Cultured
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Diploidy
- Escherichia coli
- Fibroblasts
- G1 Phase
- Homeodomain Proteins
- Humans
- Nuclear Proteins
- Phenotype
- Phosphorylation