Article
CYP19 (TTTA)n polymorphism and breast cancer risk in Brazilian women.
Toxicology letters - 20 Jun 2006
Ribeiro Fabiana Siqueira, de Amorim Lídia Maria da Fonte, de Almeida Simão Tatiana, Mendonça Gulnar Azevedo, de Moura Gallo Cláudia Vitória, Pinto Luis Felipe Ribeiro
Abstract excerpt
A prolonged or increased exposure to endogenous estrogens associated with genetic factors are considered to be the main risk factors for breast cancer. The CYP19 gene encodes the enzyme aromatase, which catalyzes the conversion of androgens into estrogens. CYP19 alleles containing different numbers of tetranucleotide TTTA repeats in intron 4 have been associated with increased breast cancer risk. In this study we...
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