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Article

The mode of action of metronidazole in Helicobacter pylori: futile cycling or reduction?

The Journal of antimicrobial chemotherapy - 1 Jan 1998

Jorgensen M A, Manos J, Mendz G L, Hazell S L

Abstract excerpt

The effects of metronidazole on catalase-positive and spontaneous catalase-negative mutants of Helicobacter pylori were studied to investigate whether the action of metronidazole on this microaerophilic organism occurs by reactive oxygen species generated by futile cycling or by the reduction of metronidazole to its active form. Increased sensitivity would be expected to occur in catalase-negative mutants if the...

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Source

Identifiers

PMID: 9511039
DOI: 10.1093/jac/41.1.67

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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