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The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori

1 Jun 1999

Abstract excerpt

It was recently demonstrated that inactivation of the rdxA gene, which encodes an oxygen-insensitive NADPH nitroreductase, is associated with the development of resistance to metronidazole by Helicobacter pylori. In order to further evaluate the contribution of rdxA to metronidazole resistance, the sequence of the rdxA gene was determined for a series of metronidazole-sensitive and -resistant isolates derived...

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PMID: 10404313
DOI: 10.1093/jac/43.6.753

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The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pyloriPMID 10404313Read ↗

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