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Article

Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori.

Archives of biochemistry and biophysics - 15 Aug 2001

Jorgensen M A, Trend M A, Hazell S L, Mendz G L

Abstract excerpt

Susceptibility of Helicobacter pylori to the antibiotic metronidazole has been attributed to the activity of an oxygen-insensitive NADPH-dependent nitroreductase (RdxA), with resistance to this antimicrobial arising from null mutations in rdxA. To obtain a better understanding of the factors invo...

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Identifiers

PMID: 11488591
DOI: 10.1006/abbi.2001.2427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11488591-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori.PMID 11488591Read ↗

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Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.Semantic proximity Read ↗

Analysis of allelic variants of rdxA associated with metronidazole resistance in Helicobacter pylori: detection of common genotypes in rdxA by multiplex allele-specific polymerase chain reaction.Semantic proximity Read ↗

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Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori.Semantic proximity Read ↗

The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pyloriSemantic proximity Read ↗

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Analysis of <i>rdxA</i> and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of <i>Helicobacter pylori</i>Semantic proximity Read ↗

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