Article
Dependence of BSAP repressor and activator functions on BSAP concentration.
Science (New York, N.Y.) - 20 Mar 1998
Wallin J J, Gackstetter E R, Koshland M E
Abstract excerpt
During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective targeting of BSAP activities was shown to be regulated by a concentration-dependent mechanism whereby activator motifs for BSAP had a 20-fold higher binding affinity than repressor motifs. An exchange of activator and repressor motifs, however, showed that the...
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