Article
Mitochondrial deoxyribonucleic acid 3256C-T mutation in a Japanese family with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Mar 1998
Hirai M, Suzuki S, Onoda M, Hinokio Y, Hirai A, Ohtomo M, Chiba M, Kasuga S, Hirai S, Satoh Y, Akai H, Miyabayashi S, Toyota T
Abstract excerpt
Accumulating reports indicate a relationship between mitochondrial DNA mutation and impaired glucose-induced insulin secretion leading to a subtype of noninsulin-dependent diabetes mellitus. DNA from a 45-yr-old Japanese woman with noninsulin-dependent diabetes mellitus and muscle atrophy was isolated and studied for mitochondrial DNA mutations. We identified a mitochondrial DNA C-T heteroplasmic mutation at...
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