Article
Prevalence and clinical characterization of Japanese diabetes mellitus with an A-to-G mutation at nucleotide 3243 of the mitochondrial tRNA(Leu(UUR)) gene.
The Journal of clinical endocrinology and metabolism - 1 Apr 1995
Odawara M, Sasaki K, Yamashita K
Abstract excerpt
An A-to-G mutation at nucleotide position 3243 of the mitochondrial genome has been associated with insulin-dependent diabetes mellitus (IDDM) and with noninsulin-dependent diabetes mellitus (NIDDM) with deafness. We investigated the prevalence of this mutation in Japanese patients with IDDM, NID...
Topics
- Adult
- Aged
- Base Sequence
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Female
- Genes
- Glucose Intolerance
- Humans
- Male
- Middle Aged
- Mitochondria
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Prevalence
- RNA, Transfer, Leu