Article
The tRNA(Gly) T10003C mutation in mitochondrial haplogroup M11b in a Chinese family with diabetes decreases the steady-state level of tRNA(Gly), increases aberrant reactive oxygen species production, and reduces mitochondrial membrane potential.
Molecular and cellular biochemistry - 1 Oct 2015
Li Wei, Wen Chaowei, Li Weixing, Wang Hailing, Guan Xiaomin, Zhang Wanlin, Ye Wei, Lu Jianxin
Abstract excerpt
Mitochondrial diabetes originates mainly from mutations located in maternally transmitted, mitochondrial tRNA-coding genes. In a genetic screening program of type 2 diabetes conducted with a Chinese Han population, we found one family with suggestive maternally transmitted diabetes. The proband's mitochondrial genome was analyzed using DNA sequencing. Total 42 known nucleoside changes and 1 novel variant were...
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