Article
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.
The New England journal of medicine - 7 Apr 1994
Kadowaki T, Kadowaki H, Mori Y, Tobe K, Sakuta R, Suzuki Y, Tanabe Y, Sakura H, Awata T, Goto Y
Abstract excerpt
BACKGROUND: Several families have been described in which a mutation of mitochondrial DNA, the substitution of guanine for adenine (A-->G) at position 3243 of leucine transfer RNA, is associated with diabetes mellitus and deafness. The prevalence, clinical features, and pathophysiology of diabetes with this mutation are largely undefined. METHODS: We studied 55 patients with insulin-dependent diabetes mellitus...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Child
- Child, Preschool
- DNA, Mitochondrial
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Female
- Humans